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Invitrogen™ Tramadol Polyclonal Antibody
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Catalog No. PIPA175470
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PIPA175470 1 mg
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Catalog No. PIPA175470 Supplier Invitrogen™ Supplier No. PA175470
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Description

Sheep Polyclonal Antibody

Working Concentration: 2.5 μg/mL. Sensitivity: 10 ng/mL Tramadol hydrochloride produces 78% inhibition in a competitive ELISA employing Tramadol polyclonal antibody.

Tramadol is only found in individuals that have used or taken this drug. It is a narcotic analgesic proposed for moderate to severe pain. It may be habituating. [PubChem] Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors. [National Center for Biotechnology Information. PubChem Compound Database; CID=33741].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Tramadol
Applications ELISA
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Alias C16H25NO2; Ralivia; Tramal; Ultram
Host Species Sheep
Immunogen Tramadol(3)-BTG.
Purification Method Purified
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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