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Invitrogen™ TRANK1 Polyclonal Antibody
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Catalog No. PIPA557300
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100 μL
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PIPA557300 100 μL
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Catalog No. PIPA557300 Supplier Invitrogen™ Supplier No. PA557300
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CKLADSIKAI CNAYNRGLSC VLRKKLKGIN KGQVSANMKI QKRIPRCYVE DTEAEKGREH VNPEYFPPAS AVETEYNIMK FHSFST Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.

The TRANK1 gene encodes the tetratricopeptide repeat and ankyrin repeat containing 1 protein, which has been associated with neurodevelopmental and psychiatric conditions, particularly bipolar disorder and schizophrenia. Located on chromosome 9, this gene contains both tetratricopeptide repeats and ankyrin repeats, which contribute to protein-protein interactions and structural stability. TRANK1 is thought to possibly participate in cellular functions related to brain development and synaptic transmission, impacting neuronal signaling and cognitive processes. Genetic studies have identified variations in the TRANK1 gene that may alter its expression, influencing susceptibility to bipolar disorder by modulating pathways related to neurotransmitter regulation and neuroplasticity. The specific mechanisms by which TRANK1 influences psychiatric disorders remain under investigation, but it is hypothesized that TRANK1's interaction with other proteins involved in signal transduction could be pivotal. Given its potential linkage to complex neurological disorders, TRANK1 serves as a significant focal point for studies aiming to understand the genetic basis of these conditions and develop targeted interventions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRANK1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TRANK1
Gene Accession No. O15050
Gene Alias KIAA0342; LBA1; Lupus brain antigen 1 homolog; tetratricopeptide repeat and ankyrin repeat containing 1; TPR and ankyrin repeat-containing protein 1; TRANK1
Gene Symbols TRANK1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TRANK1. Recombinant protein control fragment (Product #RP-96430).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9881
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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