Transferrin Receptor Monoclonal Antibody (BGX.24), PE, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA112158

Catalog No. 01-670-877

Description

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Specifications

• Antigen: Transferrin Receptor
• Classification: Monoclonal
• Conjugate: PE
• Gene: TFRC
• Gene Alias: 2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
• Host Species: Mouse
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 7037
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Flow Cytometry
• Clone: BGX.24
• Formulation: PBS with 0.2% carrier protein and 0.08% sodium azide
• Gene Accession No.: P02786
• Gene Symbols: TFRC
• Immunogen: Blast cells from pokeweed mitogen-stimulated peripheral blood cells
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov