Invitrogen™ Transferrin Receptor Monoclonal Antibody (ICO-92)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA17657

Catalog No. 01-670-391

Description

MA1-7657 detects Transferrin receptor from human samples. MA1-7657 has been successfully used in flow cytometry procedures. The MA1-7657 immunogen is a Transferrin receptor on activated T-B-cells.

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Specifications

• Antigen: Transferrin Receptor
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.2% gelatin, 0.5% saccharose and 0.1% sodium azide; pH 7.4
• Gene Accession No.: P02786
• Gene Symbols: TFRC
• Immunogen: Transferrin receptor on activated T-B-cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry
• Clone: ICO-92
• Conjugate: Unconjugated
• Gene: TFRC
• Gene Alias: 2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7037
• Content And Storage: 4°C short term, -80°C long term
• Form: Liquid