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Invitrogen™ Transferrin Receptor Polyclonal Antibody
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Catalog No. PIPA527739
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100 μL
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PIPA527739 100 μL
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Catalog No. PIPA527739 Supplier Invitrogen™ Supplier No. PA527739
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Jurkat, Raji, NCI-H929, K562, HL-60, NIH3T3. Predicted reactivity: Dog (81%), Cat (86%), Pig (82%), Rhesus Monkey (94%), Bovine (84%), Guinea pig (80%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Transferrin Receptor
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.47 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol, 1% BSA and 0.025% ProClin 300; pH 7
Gene TFRC
Gene Accession No. P02786, Q62351
Gene Alias 2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Gene Symbols TFRC
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Extracellular domain of human CD71. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22042, 7037
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Frequently Asked Questions (FAQs)

Does the Transferrin Receptor Polyclonal Antibody (Cat. No. PA527739) have cross-reactivity to chickens or avians, besides humans and mouse?

There is a 58.8% identity in 160 residues overlap with this chicken sequence in the UniProt Database. Unfortunately, we don’t have experimental data to show whether or not 58.8% homology can sufficiently show cross-reactivity with chicken or avians.

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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