Transgelin/TAGLN/SM22 alpha Antibody (TAGLN/247), Alexa Fluor™ 594, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP247688AF594

Catalog No. NP247688A94

Description

Transgelin/TAGLN/SM22 alpha Monoclonal specifically detects Transgelin/TAGLN/SM22 alpha in Human, Mouse, Porcine, Bovine, Rabbit samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Transgelin/TAGLN/SM22 alpha
• Classification: Monoclonal
• Conjugate: Alexa Fluor 594
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: TAGLN
• Immunogen: Recombinant full-length human Transgelin/TAGLN/SM22 alpha protein. (Uniprot: Q01995)
• Quantity: 0.1 mL
• Gene ID (Entrez): 6876.0
• Target Species: Human, Mouse, Pig, Primate, Rabbit
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
• Clone: TAGLN/247
• Dilution: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
• Gene Alias: DKFZp686P11128, Protein WS3-10, SM2222 kDa actin-binding protein, SMCCDKFZp686B01212, Smooth muscle protein 22-alpha, TAGLN1, transgelin, transgelin variant 2, WS3-10SM22-alpha
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Primary or Secondary: Primary
• Test Specificity: This monoclonal antibody recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
• Content And Storage: Store at 4°C in the dark.