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Transglutaminase 2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988665
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50-198-8665 100 μL
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Catalog No. 50-198-8665 Supplier Bioss Supplier No. BS8589R
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Description

Rabbit Polyclonal Antibody

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer′s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

Specifications

Antigen Transglutaminase 2
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene TGM2
Gene Accession No. P21980
Gene Alias C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; G alpha h; G[a]h; G-ALPHA-h; GNAH; LOC100352148; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase C; TGase H; TGase2; TGase-2; TGase-H; TgaseII; TGC; Tgm2; Tissue transglutaminase; tissue-type transglutaminase; transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase-2; tTG; tTGas
Gene Symbols TGM2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Transglutaminase 2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7052
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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