Invitrogen™ TRBP Recombinant Rabbit Monoclonal Antibody (9E6C9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538184

Catalog No. PIMA538184

Description

Positive Samples: Mouse testis, Rat brain Immunogen sequence: RFIEIGSGTS KKLAKRNAAA KMLLRVHTVP LDARDGNEVE PDDDHFSIGV GSRLDGLRNR GPGCTWDSLR NSVGEKILSL RSCSLGSLGA LGPACCRVLS E.

TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.

Specifications

• Antigen: TRBP
• Classification: Recombinant Monoclonal
• Concentration: 0.8 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P97473, Q15633, Q3SWU0
• Gene Symbols: TARBP2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TARBP2 (Q15633).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 9E6C9
• Conjugate: Unconjugated
• Gene: TARBP2
• Gene Alias: fj51e12; HAMAP-Rule:MF_03034}; LOQS; Prbp; PRM-1 RNA-binding protein; protamine-1 RNA-binding protein; RISC-loading complex subunit tarbp2; RISC-loading complex subunit TARBP2 {ECO:0000255; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR (HIV-1) RNA binding protein 2; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2; TARBP2 subunit of RISC loading complex; TARBP2, RISC loading complex RNA binding subunit; trans-activation responsive RNA-binding protein; trans-activation-responsive RNA-binding protein; TRBP; TRBP1; TRBP2; wu:fj51e12; zgc:63778
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21357, 363006, 6895
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov