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TREM-1 (CD354) Mouse anti-Human, Brilliant Violet 786, Clone: 6B1, BD Optibuild™

Catalog No. BDB743743 Shop All BD Biosciences Products
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BDB743743 50 μg
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Catalog No. BDB743743 Supplier BD Biosciences Supplier No. 743743
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Description

Mouse Monoclonal Antibody

The 6B1monoclonal antibody specifically binds to TREM-1 (Triggering Receptor Expressed on Myeloid Cells 1 or Triggering Receptor Expressed on Monocytes 1) which is also known as CD354. CD354 is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. CD354 is highly expressed by neutrophils and monocytes. It is also reportedly expressed at lower levels by a variety of cells including subsets of T and B cells, NK cells and dendritic cells. Its expression is upregulated on leucocytes in response to microbial lipopolysaccharide, eg, during microbial infections or sepsis. CD354 activation triggers the release of proinflammatory cytokines and chemokines. A soluble form of CD354 has been described that may play a protective role in some infectious disease states.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TREM-1 (CD354)
Classification Monoclonal
Clone 6B1
Concentration 0.2mg/mL
Conjugate Brilliant Violet 786
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias TREM1, Triggering receptor expressed on myeloid cells 1
Host Species Mouse
Immunogen Human Trem-1 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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