Invitrogen™ TREX1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5111242

Catalog No. PIPA5111242

Description

Immunogen sequence: VDAHARPFGT IRPMYGVTAS ARTKPRPSAV TTTAHLATTR NTSPSLGESR GTKDLPPVKD PGALSRE.

Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

Specifications

• Antigen: TREX1
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NSU2
• Gene Symbols: TREX1
• Immunogen: Recombinant Protein corresonding to Human TREX1. Recombinant protein control fragment (Product #RP-108375).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry
• Conjugate: Unconjugated
• Gene: TREX1
• Gene Alias: 1661; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; AGS1; AU041952; CRV; Deoxyribonuclease III; DNase III; DRN3; HERNS; RGD1309596; three prime exonuclease 1; three prime repair exonuclease 1; three-prime repair exonuclease 1; Trex1; trophoblast expressed 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11277
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov