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Invitrogen™ TREX1 Polyclonal Antibody
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Catalog No. PIPA5111242
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100 μL
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PIPA5111242 100 μL
PIPA5111063 100 μL
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Catalog No. PIPA5111242 Supplier Invitrogen™ Supplier No. PA5111242
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VDAHARPFGT IRPMYGVTAS ARTKPRPSAV TTTAHLATTR NTSPSLGESR GTKDLPPVKD PGALSRE Highest antigen sequence indentity to the following orthologs: Rat - 54%, Mouse - 54%.

Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TREX1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TREX1
Gene Accession No. Q9NSU2
Gene Alias 1661; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; AGS1; AU041952; CRV; Deoxyribonuclease III; DNase III; DRN3; HERNS; RGD1309596; three prime exonuclease 1; three prime repair exonuclease 1; three-prime repair exonuclease 1; Trex1; trophoblast expressed 1
Gene Symbols TREX1
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human TREX1. Recombinant protein control fragment (Product #RP-108375).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11277
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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