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Invitrogen™ TREX2 Polyclonal Antibody
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Catalog No. PIPA562906
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100 μL
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PIPA562906 100 μL
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Catalog No. PIPA562906 Supplier Invitrogen™ Supplier No. PA562906
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RAETFVFLDL EATGLPSVEP EIAELSLFAV HRSSLENPEH DESGALVLP Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.

TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TREX2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TREX2
Gene Accession No. Q9BQ50
Gene Alias 3'-5' exonuclease TREX2; 3'-5' exonuclease TREX2 long form; RGD1562245; Three prime repair exonuclease 2; Trex2
Gene Symbols TREX2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TREX2. Recombinant protein control fragment (Product #RP-101552).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11219
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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