Invitrogen™ TRF2 Monoclonal Antibody (4A794.15)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA141001

Catalog No. 01-676-430

Description

The TRF2 antibody is referred to as both clone 4A794.15 and 4A794 in the published literature. This antibody recognizes full-length TRF2 as well as TRF2 forms lacking both the N-terminal basic domain (B) and the telobox Myb-like C-terminal DNA-binding domain (M). TRF2 forms missing the B and M domains are often referred to as mutant TRF2.Although the exact epitope recognized by the TRF2 antibody has not been mapped, the scientific literature indicates it is in the D or L domain, but not in the B or M domain. Suggested positive control: HL-60, antigen standard for TERF2 (transient overexpression lysate).

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

Specifications

• Antigen: TRF2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O35144, Q15554
• Gene Symbols: TERF2
• Immunogen: Full-length TRF2 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Marsupial, Deer
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ChIP Assay, ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Proximity Ligation Assay, Immunocytochemistry
• Clone: 4A794.15
• Conjugate: Unconjugated
• Gene: TERF2
• Gene Alias: Telomeric DNA-binding protein; telomeric repeat binding factor 2; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TERF2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 21750, 361403, 7014
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid