Invitrogen™ TRF2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5110658	100 μL

Catalog No. PIPA5110658 Supplier Invitrogen™ Supplier No. PA5110658

Description

Rabbit Polyclonal Antibody

Immunogen sequence: DIMQALLVRP LGKEHTVSRL LRVMQCLSRI EEGENLDCSF DMEAELTPLE SAINVLEMIK TEFTLTEAVV ESSRKLVKEA AVIICIKNKE FEKASKILKK HMSKDPTTQK LRNDLLNIIR EKNLAHPVIQ NF Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 96%.

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

Specifications

• Antigen: TRF2
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: TERF2
• Gene Accession No.: Q15554
• Gene Alias: Telomeric DNA-binding protein; telomeric repeat binding factor 2; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TERF2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
• Gene Symbols: TERF2
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human TRF2. Recombinant protein control fragment (Product #RP-101880).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7014
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG