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TRF2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501558466
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50-155-8466 100 μL
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Catalog No. 50-155-8466 Supplier Bethyl Laboratories, Inc Supplier No. A300796A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (1). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (2). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (2). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3).

Specifications

Antigen TRF2
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene TERF2
Gene Accession No. Q15554
Gene Alias TRBF2, TRF2
Gene Symbols TERF2
Host Species Rabbit
Immunogen Between 375 and 425
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7014
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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