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Tocris Bioscience™ tri-GalNAc biotin
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Catalog No. 763550U
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50 μg
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763550U 50 μg
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Catalog No. 763550U Supplier Tocris Bioscience™ Supplier No. 7635/50U
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Description

Biotinylated ASGPR ligand for LYTAC research and development

Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).

Specifications

Quantity 50 μg
Target Degrader Building Blocks
Molecular Formula C83H146N14O34S
Purity 0.9
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