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Tocris Bioscience™ tri-GalNAc-PEG3-Azide
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Catalog No. 80151
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80-151 1 mg
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Catalog No. 80-151 Supplier Tocris Bioscience™ Supplier No. 8015/1
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Description

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Specifications

CAS 2925590-71-0
Quantity 1 mg
Target Degrader Building Blocks
Molecular Formula C70H125N13O31
Purity 0.9
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