TRIB1/GIG2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2159	100 μL

Catalog No. 50-198-2159 Supplier Bioss Supplier No. BS12343R

Description

Rabbit Polyclonal Antibody

TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.

Specifications

• Antigen: TRIB1/GIG2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: TRIB1
• Gene Accession No.: Q96RU8
• Gene Alias: A530090O15Rik; C8FW; GIG2; GIG-2; G-protein-coupled receptor induced protein; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; phosphoprotein regulated by mitogenic pathways; SKIP1; Trb1; TRB-1; Trib1; Tribbles homolog 1; tribbles homolog 1 (Drosophila); tribbles pseudokinase 1; tribbles-like protein 1
• Gene Symbols: TRIB1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human TRIB1/GIG2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10221
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG