TRIB1 Mouse anti-Human, Clone: OTI1F11, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805372

Catalog No. 50-166-7402

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.

Specifications

• Antigen: TRIB1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TRIB1
• Gene Alias: C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10221
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI1F11
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q96RU8
• Gene Symbols: TRIB1
• Immunogen: Full length human recombit protein of human TRIB1 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1