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TRIB1 Mouse anti-Human, Clone: OTI8C8, liquid, TrueMAB™
SDP

Catalog No. 501680620
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50-168-0620 100 μL
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Catalog No. 50-168-0620 Supplier OriGene Supplier No. TA805274
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Description

Mouse Monoclonal Antibody

TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.

Specifications

Antigen TRIB1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI8C8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene TRIB1
Gene Accession No. Q96RU8
Gene Alias C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1
Gene Symbols TRIB1
Host Species Mouse
Immunogen Full length human recombit protein of human TRIB1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10221
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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