Invitrogen™ TRIF Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523467

Catalog No. PIPA523467

Description

Suggested positive control: antigen standard for TICAM1 (transient overexpression lysate), mouse spleen tissue or mouse spleen protein.

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Specifications

• Antigen: TRIF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TICAM1
• Gene Alias: AW046014; AW547018; hCG_39321; HSD34; IIAE6; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; PRVTIRB; Putative NF-kappa-B-activating protein 502H; RNF36; TI; Ticam1; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; TIR-domain containing adaptor inducing interferon-beta; toll like receptor adaptor molecule 1; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; toll-interleukin I receptor domain containing adaptor molecule 1; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1; TRIF
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100623776, 106759, 363328
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q80UF7
• Gene Symbols: TICAM1
• Immunogen: Synthetic peptide made to an internal portion of the mouse TRIF protein (between amino acids 100-180).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat, Pig
• Product Type: Antibody
• Isotype: IgG