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Invitrogen™ TRIF Polyclonal Antibody

Catalog No. PIPA588150
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100 μL
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PIPA588150 100 μL
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Catalog No. PIPA588150 Supplier Invitrogen™ Supplier No. PA588150

Description

Rabbit Polyclonal Antibody

Positive Samples: A-549, U-251MG, 22RV1, Mouse spleen, Mouse eye, Rat spleen; Cellular Location: Cytoplasmic vesicle, autophagosome Immunogen sequence: RPIDGVSDWS QGCSLRSTGS PASLASNLEI SQSPTMPFLS LHRSPHGPSK LCDDPQASLV PEPVPGGCQE PEEMSWPPSG EIASPPELPS SPPPGLPEVA P.

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIF
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.79 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TICAM1
Gene Accession No. Q80UF7, Q8IUC6
Gene Alias AW046014; AW547018; hCG_39321; HSD34; IIAE6; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; PRVTIRB; Putative NF-kappa-B-activating protein 502H; RNF36; TI; Ticam1; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; TIR-domain containing adaptor inducing interferon-beta; toll like receptor adaptor molecule 1; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; toll-interleukin I receptor domain containing adaptor molecule 1; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1; TRIF
Gene Symbols TICAM1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 180-280 of human TRIF / TICAM1 (NP_8915491).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 106759, 148022, 363328
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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