TRIF Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA595078

Catalog No. PIPA595078

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL.

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Specifications

• Antigen: TRIF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TICAM1
• Gene Alias: AW046014, AW547018, hCG_39321, HSD34, IIAE6, MyD88-3, Proline-rich, vinculin and TIR domain-containing protein B, PRVTIRB, Putative NF-kappa-B-activating protein 502H, RNF36, TI, Ticam1, TICAM-1, TIR domain containing adaptor inducing interferon-beta, TIR domain-containing adapter molecule 1, TIR domain-containing adapter protein inducing IFN-beta, TIR domain-containing adaptor inducing interferon-beta, TIR-domain containing adaptor inducing interferon-beta, toll like receptor adaptor molecule 1, toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta, toll-interleukin I receptor domain containing adaptor molecule 1, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, toll-like receptor adaptor molecule 1, TRIF
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 148022
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5MG BSA and 0.05MG sodium azide, 0.05MG thimerosal
• Gene Accession No.: Q8IUC6
• Gene Symbols: TICAM1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TRIF (692-712aa NNHMWNQRGSQAPEDKTQEAE).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG