TRIF (TICAM-1) Mouse anti-Human, PE, Clone: U19-709, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 566354

Catalog No. BDB566354

Description

The U19-709 monoclonal antibody specifically recognizes TIR domain-containing adapter inducing IFN-β (TRIF),which is also known as TIR domain-containing adapter molecule 1 (TICAM-1). TRIF (TICAM-1) is an intracellular adaptor protein that contains a Toll/Interleukin-1 Receptor (TIR) homology domain. Double stranded RNA (dsRNA)-bound Toll-like receptor 3 (TLR3/CD283) or lipopolysaccharide (LPS)-triggered TLR4/CD284 can interact with TRIF (TICAM-1). This leads to downstream signaling cascades involving Interferon regulatory factors (eg, IRF3 or IRF7) or nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) that induce Interferon-beta (IFN-β) expression.

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.

Specifications

• Antigen: TRIF (TICAM-1)
• Concentration: 0.2mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Gene Alias: TICAM1, PRVTIRB, MyD88-3, IIAE6
• Immunogen: Human TRIF Recombinant Protein
• Purification Method: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human

• Clone: U19-709
• Conjugate: PE
• Format: Affinity Purified
• Host Species: Mouse
• Isotype: Mouse IgG₁, κ
• Quantity: 50μg
• Storage Requirements: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Monoclonal or Polyclonal: Monoclonal