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Invitrogen™ TRIM21 Polyclonal Antibody

Catalog No. PIPA522294
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100 μL
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PIPA522294 100 μL
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Catalog No. PIPA522294 Supplier Invitrogen™ Supplier No. PA522294

Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, TRIM21-transfected 293T. Predicted reactivity: Cat (86%), Pig (81%), Rhesus Monkey (99%), Bovine (82%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM21
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.52 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene TRIM21
Gene Accession No. P19474
Gene Alias 52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro protein; 52kD Ro/SSA autoantigen; E3 ubiquitin-protein ligase TRIM21; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; RNF81; Ro(SS-A); Ro/SSA; RO52; Sicca syndrome antigen A; sjoegren syndrome type A antigen; Sjogren syndrome antigen A1; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SSA; SS-A; Ssa1; TRIM21; tripartite motif containing 21; tripartite motif protein 21; tripartite motif-containing 21; tripartite motif-containing protein 21
Gene Symbols TRIM21
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SSA1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6737
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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