Invitrogen™ TRIM21 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110517

Catalog No. PIPA5110517

Description

Immunogen sequence: GTQGERCAVH GERLHLFCEK DGKALCWVCA QSRKHRDHAM VPLEEAAQEY QEKLQVALGE LRRKQELAEK LEVEIAIKRA DWKKTVETQK SRIHAEFVQQ KNFLVEEEQR QLQELEKDER EQLRILGEKE AKLAQQSQAL QELISELDRR CHSSALELLQ EVIIVLERSE SWNLKDLDIT SPELRSVCHV PGLKKMLRTC AVHITLDPDT ANPWLILSED RRQVRLGDTQ QSIPGNEERF DSYPMVLGA.

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Specifications

• Antigen: TRIM21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRIM21
• Gene Alias: 52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro protein; 52kD Ro/SSA autoantigen; E3 ubiquitin-protein ligase TRIM21; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; RNF81; Ro(SS-A); Ro/SSA; RO52; Sicca syndrome antigen A; sjoegren syndrome type A antigen; Sjogren syndrome antigen A1; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SSA; SS-A; Ssa1; TRIM21; tripartite motif containing 21; tripartite motif protein 21; tripartite motif-containing 21; tripartite motif-containing protein 21
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20821, 308901, 6737
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.43 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P19474, Q62191
• Gene Symbols: TRIM21
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 86-334 of human TRIM21/SS-A (NP_0031322).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG