Invitrogen™ TRIM25 Monoclonal Antibody (5B5B10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531936

Catalog No. PIMA531936

Description

MA5-31936 has been tested in indirect ELISA.

TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.

Specifications

• Antigen: TRIM25
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q14258, Q61510
• Gene Symbols: TRIM25
• Immunogen: Purified recombinant fragment of human TRIM25 (AA: 211-360) expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 5B5B10
• Conjugate: Unconjugated
• Gene: TRIM25
• Gene Alias: AA960166; AL022677; E3 ubiquitin/ISG15 ligase TRIM25; Efp; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; RNF147; Trim25; tripartite motif containing 25; tripartite motif protein 25; tripartite motif protein TRIM25; tripartite motif-containing 25; tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; Zfp147; Zinc finger protein 147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; Znf147
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 217069, 7706
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid