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Invitrogen™ TRIM25 Recombinant Rabbit Monoclonal Antibody (4Q0D2)
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Catalog No. PIMA535488
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100 μL
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PIMA535488 100 μL
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Catalog No. PIMA535488 Supplier Invitrogen™ Supplier No. MA535488
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: SPNAQVACDH CLKEAAVKTC LVCMASFCQE HLQPHFDSPA FQDHPLQPPV RDLLRRKCSQ HNRLREFFCP EHSECICHIC LVEHKTCSPA SLSQASADLE A.

TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM25
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 4Q0D2
Concentration 0.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TRIM25
Gene Accession No. Q14258
Gene Alias AA960166; AL022677; E3 ubiquitin/ISG15 ligase TRIM25; Efp; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; RNF147; Trim25; tripartite motif containing 25; tripartite motif protein 25; tripartite motif protein TRIM25; tripartite motif-containing 25; tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; Zfp147; Zinc finger protein 147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; Znf147
Gene Symbols TRIM25
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TRIM25 (Q14258).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7706
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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