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Invitrogen™ TRIM30 Polyclonal Antibody
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Catalog No. PIPA520590
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100 μg
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Catalog No. Quantity
PIPA520590 100 μg
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Catalog No. PIPA520590 Supplier Invitrogen™ Supplier No. PA520590
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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse spleen tissue lysate. PA5-20590 can be used with blocking peptide PEP-0710.

TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-kappa-B activation. The importance of TRIM30 in the attenuation or termination of NF-kappa-B activation suggests that targeting of TAB2 and TAB3 by TRIM30alpha may be a mechanism for modulating many types of immune responses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM30
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Trim30a
Gene Accession No. P15533
Gene Alias Down regulatory protein of interleukin-2 receptor; regulatory protein, T lymphocyte 1; RGD1563970; Rpt1; Rpt-1; Trim30; Trim30a; tripartite motif protein 30; tripartite motif-containing 30; tripartite motif-containing 30A; tripartite motif-containing protein 30; Tripartite motif-containing protein 30A
Gene Symbols Trim30a
Host Species Rabbit
Immunogen A 16 amino acid peptide near the carboxy terminus of the mouse TRIM30.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20128
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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