Invitrogen™ TRIM5 alpha/beta/gamma/delta/epsilon/iota Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595970

Catalog No. PIPA595970

Description

Immunogen sequence: EKLLLFCQED GKVICWLCER SQEHRGHHTF LTEEVAREYQ VKLQAALEML RQKQQEAEEL EADIREEKAS WKTQIQYDKT NVLADFEQLR DILDWEESNE L; Positive Samples: HeLa, Jurkat, HepG2, Mouse stomach, Mouse thymus; Cellular Location: Cytoplasm, Nucleus, P-body.

TRIM5a is a 493 amino acid member of the large tripartite motif protein (TRIM) family. TRIM proteins are composed of three zinc-binding domains, a RING, a B-box 2 and a coiled-coil domain, and they use homomultimerization to identify different cell compartments. Some TRIM proteins, such as TRIM5a, also possess a carboxy-terminal B30.2 (SPRY) domain and localize to the cytoplasm. TRIM5a mediates innate intracellular retroviral resistance, which is dependent on its carboxy-terminal domain. The three variable regions of the B30.2 domain form loops on one side of the B30.2 core structure of TRIM5a which may form a binding surface for the virus. TRIM5a trimerization plays a major role in its affinity for the retroviral capsid, and in its ability to inhibit virus infection. The linker region between the coiled-coil and B30.2 domains of TRIM5a is required for this trimerization. TRIM5a blocks infection after the virus has entered the cell.

Specifications

• Antigen: TRIM5 alpha/beta/gamma/delta/epsilon/iota
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRIM5
• Gene Alias: EG667823; Gm8833; ring finger protein 88; RING-type E3 ubiquitin transferase TRIM5; RNF88; TRIM5; trim5a; TRIM5alpha; tripartite motif containing 5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa; tripartite motif protein TRIM5; tripartite motif-containing 5; tripartite motif-containing protein 5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 667823, 85363
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.53 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9C035
• Gene Symbols: TRIM5
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TRIM5 (NP_1490832).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov