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Invitrogen™ TRIM5 alpha/beta/gamma/delta/epsilon/iota Polyclonal Antibody
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Catalog No. PIPA595970
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PIPA595970 100 μL
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Catalog No. PIPA595970 Supplier Invitrogen™ Supplier No. PA595970
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EKLLLFCQED GKVICWLCER SQEHRGHHTF LTEEVAREYQ VKLQAALEML RQKQQEAEEL EADIREEKAS WKTQIQYDKT NVLADFEQLR DILDWEESNE L; Positive Samples: HeLa, Jurkat, HepG2, Mouse stomach, Mouse thymus; Cellular Location: Cytoplasm, Nucleus, P-body.

TRIM5a is a 493 amino acid member of the large tripartite motif protein (TRIM) family. TRIM proteins are composed of three zinc-binding domains, a RING, a B-box 2 and a coiled-coil domain, and they use homomultimerization to identify different cell compartments. Some TRIM proteins, such as TRIM5a, also possess a carboxy-terminal B30.2 (SPRY) domain and localize to the cytoplasm. TRIM5a mediates innate intracellular retroviral resistance, which is dependent on its carboxy-terminal domain. The three variable regions of the B30.2 domain form loops on one side of the B30.2 core structure of TRIM5a which may form a binding surface for the virus. TRIM5a trimerization plays a major role in its affinity for the retroviral capsid, and in its ability to inhibit virus infection. The linker region between the coiled-coil and B30.2 domains of TRIM5a is required for this trimerization. TRIM5a blocks infection after the virus has entered the cell.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM5 alpha/beta/gamma/delta/epsilon/iota
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.53 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene TRIM5
Gene Accession No. Q9C035
Gene Alias EG667823; Gm8833; ring finger protein 88; RING-type E3 ubiquitin transferase TRIM5; RNF88; TRIM5; trim5a; TRIM5alpha; tripartite motif containing 5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa; tripartite motif protein TRIM5; tripartite motif-containing 5; tripartite motif-containing protein 5
Gene Symbols TRIM5
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TRIM5 (NP_1490832).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 667823, 85363
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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