Invitrogen™ TRIM56 Monoclonal Antibody (OTI8E12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527076

Catalog No. PIMA527076

Description

TRIM56 Monoclonal Antibody for Western Blot, IHC (P)

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). [UniProt].

Specifications

• Antigen: TRIM56
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9BRZ2
• Gene Symbols: TRIM56
• Immunogen: Human recombinant protein fragment corresponding to amino acids 311-554 of TRIM56 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI8E12
• Conjugate: Unconjugated
• Gene: TRIM56
• Gene Alias: E3 ubiquitin-protein ligase TRIM56; RING finger protein 109; RING-type E3 ubiquitin transferase TRIM56; RNF109; TRIM56; tripartite motif containing 56; tripartite motif-containing protein 56
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81844
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid