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Invitrogen™ TRIM56 Polyclonal Antibody
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Catalog No. PIPA555061
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100 μL
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PIPA555061 100 μL
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Catalog No. PIPA555061 Supplier Invitrogen™ Supplier No. PA555061
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PECRETVPVP PEGVASFKTN FFVNGLLDLV KARACGDLRA GKPACALCPL VGGTSTGGPA TARCLDCADD LCQACADGHR C Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 29%.

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM56
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TRIM56
Gene Accession No. Q9BRZ2
Gene Alias E3 ubiquitin-protein ligase TRIM56; RING finger protein 109; RING-type E3 ubiquitin transferase TRIM56; RNF109; TRIM56; tripartite motif containing 56; tripartite motif-containing protein 56
Gene Symbols TRIM56
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TRIM56. Recombinant protein control fragment (Product #RP-92861).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81844
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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