TRIM56 Mouse anti-Human, Clone: OTI5A1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527066
DescriptionE3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to ft.Lys-63 ft.-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|RNF109, E3 ubiquitin-protein ligase TRIM56, RING finger protein 109, tripartite motif-containing 56, tripartite motif-containing protein 56|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 311-554 of TRIM56 produced in E.coli|
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