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Invitrogen™ TRIM71 Polyclonal Antibody
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Catalog No. PIPA558265
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100 μL
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PIPA558265 100 μL
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Catalog No. PIPA558265 Supplier Invitrogen™ Supplier No. PA558265
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IKSFGFVSSG AFAPLTKATG DGLKRALQGK VASFTVIGYD HDGEPRLSGG DLMSAVVLGP DGNLFGAEVS DQQNG Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM71
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TRIM71
Gene Accession No. Q2Q1W2
Gene Alias 2610206G21Rik; abnormal cell LINeage LIN-41; AL022943; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41); Drosophila dappled/ vertebrate TRipartite Motif protein related; E3 ubiquitin-protein ligase TRIM71; Gm1127; homolog of C. elegans Lin-41; Lin41; LIN-41; lin-41 homolog; mLin41; mlin-41; protein lin-41 homolog; RGD1566388; RING-type E3 ubiquitin transferase TRIM71; Trim71; tripartite motif containing 71; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing 71; tripartite motif-containing protein 71
Gene Symbols TRIM71
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TRIM71. Recombinant protein control fragment (Product #RP-96487).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 131405
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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