Invitrogen™ TRIM71 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA519281

Catalog No. PIPA519281

Description

This antibody is predicted to react with bovine, canine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.

Specifications

• Antigen: TRIM71
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRIM71
• Gene Alias: 2610206G21Rik; abnormal cell LINeage LIN-41; AL022943; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41); Drosophila dappled/ vertebrate TRipartite Motif protein related; E3 ubiquitin-protein ligase TRIM71; Gm1127; homolog of C. elegans Lin-41; Lin41; LIN-41; lin-41 homolog; mLin41; mlin-41; protein lin-41 homolog; RGD1566388; RING-type E3 ubiquitin transferase TRIM71; Trim71; tripartite motif containing 71; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing 71; tripartite motif-containing protein 71
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 131405, 636931
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q1PSW8, Q2Q1W2
• Gene Symbols: TRIM71
• Immunogen: Synthetic peptide sequence (RQVKAKSLYLQVE) corresponding to the internal amino acids of TRIM71 (aa 390-402).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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