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Invitrogen™ TRIM72 Monoclonal Antibody (A1D4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA534958

Catalog No. PIMA534958


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Description

Description

Positive Control: HCT116 cell lysates, rat skeletal muscle tissue, human pancreas tissue, A549.

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TRIM72
Monoclonal
2 mg/mL
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Q6ZMU5
TRIM72
Recombinant protein with Human TRIM72 aa 50-150.
100 μL
Primary
Human
Antibody
IgG1
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
A1D4
Unconjugated
TRIM72
BC067209; mg53; mitsugumin 53; mitsugumin-53; RGD1562778; TRIM72; trim72 {ECO:0000250; tripartite motif containing 72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; tripartite motif-containing protein 72; UniProtKB:Q8N4X6}
Mouse
Protein A
RUO
493829
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Liquid
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