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Invitrogen™ TRIM72 Monoclonal Antibody (A1D4)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA534958
Description
Positive Control: HCT116 cell lysates, rat skeletal muscle tissue, human pancreas tissue, A549.
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
Specifications
TRIM72 | |
Monoclonal | |
2 mg/mL | |
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
Q6ZMU5 | |
TRIM72 | |
Recombinant protein with Human TRIM72 aa 50-150. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
A1D4 | |
Unconjugated | |
TRIM72 | |
BC067209; mg53; mitsugumin 53; mitsugumin-53; RGD1562778; TRIM72; trim72 {ECO:0000250; tripartite motif containing 72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; tripartite motif-containing protein 72; UniProtKB:Q8N4X6} | |
Mouse | |
Protein A | |
RUO | |
493829 | |
-20°C, Avoid Freeze/Thaw Cycles, store in dark | |
Liquid |
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