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Invitrogen™ TRIM72 Polyclonal Antibody
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Catalog No. PIPA5143960
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100 μg
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Catalog No. Quantity
PIPA5143960 100 μg
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Catalog No. PIPA5143960 Supplier Invitrogen™ Supplier No. PA5143960
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Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: rat skeletal muscle tissue, rat heart tissue, mouse skeletal muscle tissue, mouse heart tissue. IHC: human skeletal muscle tissue, mouse cardiac muscle tissue, rat heart tissue. Flow: THP-1 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM72
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene TRIM72
Gene Accession No. A0JPQ4, Q1XH17, Q6ZMU5
Gene Alias BC067209; mg53; mitsugumin 53; mitsugumin-53; RGD1562778; TRIM72; trim72 {ECO:0000250; tripartite motif containing 72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; tripartite motif-containing protein 72; UniProtKB:Q8N4X6}
Gene Symbols TRIM72
Host Species Rabbit
Immunogen E.coli-derived human MG53/TRIM72 recombinant protein (Position: E28-A477).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 365377, 434246, 493829
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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