TRIM72 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-3746	Proteintech Group Inc 221511AP150UL	150 μL

Description

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.

Specifications

• Antigen: TRIM72
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q1XH17, Q6ZMU5
• Gene ID (Entrez): 434246, 493829
• Immunogen: TRIM72 Fusion Protein Ag17756
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TRIM72

• Concentration: 0.77 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: hMG53, Mg53, Mitsugumin 53, TRIM72, tripartite motif containing 72
• Gene Symbols: Trim72
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody