Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Tocris Bioscience™ Triptolide
GREENER_CHOICE

Catalog No. 325310
Click to view available options
Quantity:
1 mg
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Triptolide inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Triptolide blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.

Chemical Identifiers

CAS 38748-32-2
Molecular Formula C20H24O6

Specifications

Quantity 10 mg
Formula Weight 360.4
Purity >98%
Molecular Weight (g/mol) 360.41
Chemical Name or Material Triptolide
Recommended Storage Store at -20°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.