Invitrogen™ TRK fused gene Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565710

Catalog No. PIPA565710

Description

Immunogen sequence: LRRELIELRNK VNRLLDSLEP PGEPGPSTNI PENDTVDGRE EKSASDSSGK QSTQVMAASM SAFDPLKNQD EINKNVMSAF GLTDDQVSGP PS Highest antigen sequence identity to the following orthologs - mouse 96%, rat 97%.

TFG protein, a recently identified novel protein, is a human homolog of mouse TFG protein. It contains an N-terminal coiled-coil structure, a SPYGQ-rich region followed by octicosapeptide repeats. Research shows that TFG can modulate SHP-1 activity and is a novel member of the NF-kB pathway. The physiological functions of this protein remain largely elusive, but TFG is thought to function by associating with other proteins, including TANK and NEMO. TFG was first identified as a partner of NTRK1 and is involved in generating the thyroid TRK-T3 oncogene, as well as oncogenic rearrangements with ALK in anaplastic lymphoma and NOR1 in mixoid chondrosarcoma.

Specifications

• Antigen: TRK fused gene
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TFG
• Gene Alias: AI173908; HMSNP; protein TFG; SPG57; TF6; TFG; Trk-fused gene; TRK-fused gene protein; TRKT3; TRKT3 oncogene
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10342
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q92734
• Gene Symbols: TFG
• Immunogen: Recombinant Human TFG. Recombinant protein control fragment (Product #RP-104940).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG