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Invitrogen™ TrkC Polyclonal Antibody
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Catalog No. PIPA596445
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100 μL
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PIPA596445 100 μL
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Catalog No. PIPA596445 Supplier Invitrogen™ Supplier No. PA596445
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KTEINCRRPD DGNLFPLLEG QDSGNSNGNA SINITDISRN ITSIHIENWR SLHTLNAVDM ELYTGLQKLT IKNSGLRSIQ PRAFAKNPHL RYINLSSNRL TTLSWQLFQT LSLRELQLEQ NFFNCSCDIR WMQLWQEQGE AKLNSQNLYC INADGSQLPL FRMNISQCDL PEISVSHVNL TVREGDNAVI TCNGSGSPLP DVDWIVTGLQ SINTHQTNLN WTNVHAINLT LVNVTSEDNG FTLTCIAENV VGMSNASVAL T; Positive Samples: A-549, BT-474, HepG2, Mouse brain, MCF7, Mouse liver; Cellular Location: Membrane, Single-pass type I membrane protein.

NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TrkC
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.58 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Ntrk3
Gene Accession No. Q03351, Q16288, Q6VNS1
Gene Alias AW125844; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp145(trkC); GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); neurotrophic receptor tyrosine kinase 3; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; NTRK3; Ntrk3_tv3; TrkC; trk-C; trkC tyrosine kinase; tyrosine kinase receptor; tyrosine kinase receptor C
Gene Symbols Ntrk3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TrKC (NP_0010071571).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18213, 29613, 4916
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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