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Invitrogen™ TRMT12 Monoclonal Antibody (OTI1C9)
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Catalog No. PIMA527176
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100 μL
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PIMA527176 100 μL
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Catalog No. PIMA527176 Supplier Invitrogen™ Supplier No. MA527176
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Description

Mouse Monoclonal Antibody

TRMT12 Monoclonal Antibody for Western Blot, IHC (P)

TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRMT12
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1C9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TRMT12
Gene Accession No. Q53H54
Gene Alias 4632406N01Rik; AI449275; alpha-amino-alpha-carboxypropyl transferase TYW2; homolog of yeast tRNA methyltransferase; TRM12; Trmt12; tRNA methyltranferase 12; tRNA methyltranferase 12 homolog; tRNA methyltransferase 12; tRNA methyltransferase 12 homolog; tRNA wybutosine-synthesizing protein 2 homolog; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW synthesizing protein 2; tRNA-yW-synthesizing protein 2; TYW2
Gene Symbols TRMT12
Host Species Mouse
Immunogen Full length human recombinant protein of TRMT12 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55039
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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