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Invitrogen™ TRMT12 Polyclonal Antibody
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Catalog No. PIPA554935
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100 μL
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PIPA554935 100 μL
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Catalog No. PIPA554935 Supplier Invitrogen™ Supplier No. PA554935
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: WFTQRYREYL QRQKLFDTQH RVEKMPDGSV ALPVLGETLP EQHLQELRNR VAPGSPCMLT QLPDPVPSKR AQGCSPAQKL CLEVSRWVE Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 74%.

TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRMT12
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TRMT12
Gene Accession No. Q53H54
Gene Alias 4632406N01Rik; AI449275; alpha-amino-alpha-carboxypropyl transferase TYW2; homolog of yeast tRNA methyltransferase; TRM12; Trmt12; tRNA methyltranferase 12; tRNA methyltranferase 12 homolog; tRNA methyltransferase 12; tRNA methyltransferase 12 homolog; tRNA wybutosine-synthesizing protein 2 homolog; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW synthesizing protein 2; tRNA-yW-synthesizing protein 2; TYW2
Gene Symbols TRMT12
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TYW2. Recombinant protein control fragment (Product #RP-93938).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55039
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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