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Invitrogen™ TRMT12 Polyclonal Antibody
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Catalog No. PIPA521153
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100 μg
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PIPA521153 100 μg
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Catalog No. PIPA521153 Supplier Invitrogen™ Supplier No. PA521153
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Description

Rabbit Polyclonal Antibody

A suggested positive control is K562 cell lysate. PA5-21153 can be used with blocking peptide PEP-1267.

TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRMT12
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TRMT12
Gene Accession No. Q53H54, Q8BG71
Gene Alias 4632406N01Rik; AI449275; alpha-amino-alpha-carboxypropyl transferase TYW2; homolog of yeast tRNA methyltransferase; TRM12; Trmt12; tRNA methyltranferase 12; tRNA methyltranferase 12 homolog; tRNA methyltransferase 12; tRNA methyltransferase 12 homolog; tRNA wybutosine-synthesizing protein 2 homolog; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW synthesizing protein 2; tRNA-yW-synthesizing protein 2; TYW2
Gene Symbols TRMT12
Host Species Rabbit
Immunogen A 19 amino acid peptide near the amino terminus of human TYW2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55039, 68260
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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