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Trop-2 Mouse anti-Human, Brilliant Violet 650, Clone: 162-46, BD Optibuild™

Catalog No. BDB743275 Shop All BD Biosciences Products
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BDB743275 50 μg
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Description

Mouse Monoclonal Antibody

The 162-46 monoclonal antibody recognizes human Trop-2 which is also known as GA733-1. Trop-2 is encoded by TACSTD2 /(tumor-associated calcium signal transducer 2). It is a single-pass type-1 transmembrane glycoprotein. Trop-2 was originally identified to be expressed on human trophoblast and choriocarcinoma cell lines. Trop-2 is expressed in most human carcinomas. Trop-2 appears to be involved in the transduction of an intracellular calcium signal, although the exact physiological mechanism has yet to be elucidated.

The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 650nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination. BV650 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 650 nm. Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. BV650 will have moderate spillover into the BD Horizon™ BV711 detector.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Trop-2
Classification Monoclonal
Clone 162-46
Concentration 0.2mg/mL
Conjugate Brilliant Violet 650
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias GA733-1, TROP2, EGP-1, EGP1, GP50, M1S1, TACD2
Host Species Mouse
Immunogen Human BeWo (choriocarcinoma) Cell Line
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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