Invitrogen™ TROP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121175

Catalog No. PIPA5121175

Description

Positive test controls include: BxPC-3, A-431, Mouse kidney. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein. Immunogen sequence: HTAAQDNCTC PTNKMTVCSP DGPGGRCQCR ALGSGMAVDC STLTSKCLLL KARMSAPKNA RTLVRPSEHA LVDNDGLYDP DCDPEGRFKA RQCNQTSVCW CVNSVGVRRT DKGDLSLRCD ELVRTHHILI DLRHRPTAGA FNHSDLDAEL RRLFRERYRL HPKFVAAVHY EQPTIQIELR QNTSQKAAGD VDIGDAAYYF ERDIKGESLF QGRGGLDLRV RGEPLQVERT LIYYLDEIPP KFSM.

TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

Specifications

• Antigen: TROP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TACSTD2
• Gene Alias: 40kD glycoprotein, identified by monoclonal antibody GA733; C80403; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; EGP1; EGP-1; epithelial glycoprotein-1; GA733; GA7331; GA733-1; gastrointestinal tumor-associated antigen GA7331; GP50; Ly97; lymphocyte antigen 97; M1S1; Membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; parturition-related protein 1; Prp1; TACD2; TACSTD2; Trop2; truncated TACSTD2; tumor-associated calcium signal transducer 2; tunor-associated calcium signal transducer 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4070, 494343, 56753
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 2 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P09758, Q6P9Z6, Q8BGV3
• Gene Symbols: TACSTD2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-270 of human TROP-2 (NP_002344.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG