TRPA1 (extracellular) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5111755

Catalog No. PIPA5111755

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: (C)NSTGIIN ETSDHSE Homology: Bovine amino acid residues identical; canis - 13/14 amino acid residues identical; rat - 12/14 amino acid residues identical; mouse - 9/14 amino acid residues identical.

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

Specifications

• Antigen: TRPA1 (extracellular)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Trpa1
• Gene Alias: ANKTM1; Ankyrin-like with transmembrane domains protein 1; FEPS; nompC; Transformation-sensitive protein p120; Transient receptor potential cation channel subfamily A member 1; Trpa1; TRPA-1; TRPA1b
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 277328, 312896, 8989
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O75762, Q6RI86, Q8BLA8
• Gene Symbols: Trpa1
• Immunogen: Peptide corresponding to amino acidresidues 747-760 of human TRPA1 (1stextracellular loop)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG