Invitrogen™ TRPA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534282

Catalog No. PIPA534282

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Marmoset, Bovine (89%) Monkey, Elephant, Dog, Rabbit, Pig (84%).

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

Specifications

• Antigen: TRPA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Trpa1
• Gene Alias: Anktm1; ankyrin-like with transmembrane domains 1; ankyrin-like with transmembrane domains protein 1; FEPS; ion channel; drTRPA1; nompC; transformation-sensitive protein p120; transient receptor potential A1; transient receptor potential ankyrin 1a; transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel subfamily A member 1a; transient receptor potential cation channel, subfamily A, member 1a; transient receptor potential cation channel subfamily A member 1-like; transient receptor potential cation channel, subfamily A, member 1; transient receptor potential cation channel, subfamily A, member 1 L homeolog; transient receptor potential cation channel, subfamily A, member 1a; TRPA1; TRPA-1; trpa1.L; trpa1a; TRPA1b; XELAEV_18003616mg
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8989
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O75762
• Gene Symbols: Trpa1
• Immunogen: Synthetic 19 amino acid peptide from internal region of human TRPA1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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