Invitrogen™ TRPA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109320

Catalog No. PIPA5109320

Description

Positive Control: L929, MG-63, NIH-3T3, rat brain tissue, human skin tissue, human esophagus tissue, mouse colon tissue.

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

Specifications

• Antigen: TRPA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Trpa1
• Gene Alias: Anktm1; ankyrin-like with transmembrane domains 1; ankyrin-like with transmembrane domains protein 1; FEPS; ion channel; drTRPA1; nompC; transformation-sensitive protein p120; transient receptor potential A1; transient receptor potential ankyrin 1a; transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel subfamily A member 1a; transient receptor potential cation channel, subfamily A, member 1a; transient receptor potential cation channel subfamily A member 1-like; transient receptor potential cation channel, subfamily A, member 1; transient receptor potential cation channel, subfamily A, member 1 L homeolog; transient receptor potential cation channel, subfamily A, member 1a; TRPA1; TRPA-1; trpa1.L; trpa1a; TRPA1b; XELAEV_18003616mg
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8989
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O75762
• Gene Symbols: Trpa1
• Immunogen: Recombinant protein within Human TRPA1 aa 505-755.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov