Invitrogen™ TRPA1 Polyclonal Antibody, Biotin

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522831

Catalog No. PIPA522831

Description

The target sequence has 69% sequence homology with rat. Suggested positive control: human brain membrane fraction.

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

Specifications

• Antigen: TRPA1
• Classification: Polyclonal
• Conjugate: Biotin
• Gene: Trpa1
• Gene Alias: Anktm1; ankyrin-like with transmembrane domains 1; ankyrin-like with transmembrane domains protein 1; FEPS; ion channel; drTRPA1; nompC; transformation-sensitive protein p120; transient receptor potential A1; transient receptor potential ankyrin 1a; transient receptor potential cation channel subfamily A member 1; transient receptor potential cation channel subfamily A member 1a; transient receptor potential cation channel, subfamily A, member 1a; transient receptor potential cation channel subfamily A member 1-like; transient receptor potential cation channel, subfamily A, member 1; transient receptor potential cation channel, subfamily A, member 1 L homeolog; transient receptor potential cation channel, subfamily A, member 1a; TRPA1; TRPA-1; trpa1.L; trpa1a; TRPA1b; XELAEV_18003616mg
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100526649, 277328, 312896, 474351, 8989
• Content And Storage: 4°C, store in dark
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.96 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: O75762, Q6RI86, Q8BLA8
• Gene Symbols: Trpa1, trpa1a
• Immunogen: A synthetic peptide made to a region within the N-terminus (residues 1-100) of the human TRPA1 protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Guinea Pig, Zebrafish
• Product Type: Antibody
• Isotype: IgG